Viewing molecules, materials and molecular machines at high magnification and in three dimensions is important for research at the molecular scale and critical to nanoscience. Through an NIH major instrumentation grant and supports from UCLA, the Electron Imaging Center for Nanomachines (EICN) was established at CNSI to provide advanced electron imaging tools to see macromolecular machineries and to understand their mechanisms of action.
EICN is now able to cover nanometer to tens of micrometer size ranges, delivering valuable structural information for cell biological, biomolecular, molecular and materials sciences. The state-of-the-art EICN facility will offer all major electron imaging modalities. Currently available capabilities at EICN include single particle cryo-electron microscopy (cryoEM) at near atomic resolution, and cryo-electron tomography (cryoET) at molecular resolution, high-resolution transmission electron microscopy (TEM), as well as scanning transmission electron microscopy (STEM) and energy dispersive X-ray (EDX) analysis for mass and elementary mapping. These structural methods provide exciting opportunities to microbiologists, cell and molecular biologists, chemists and materials scientists for three-dimensional (3D) structural characterization of a wide variety of assemblies, devices and materials.
Transmission electron microscopy uses a variety of techniques to image and characterize samples. For example:
- High resolution imaging can resolve individual atoms
- Cryo-EM can reveal structures and molecular interactions of biological complexes
- STEM imaging can differentiate atom types
- X-ray spectroscopy (EDX) can quantify elemental composition
- Tomography can resolve the 3D structures of materials and biological tissues
EICN offers advanced electron imaging techniques for visualizing materials, nanomachines, and cellular structures at atomic or nanometer scales in 2D and 3D. Highly experienced staff provide the necessary trainings and can assist users with their complex electron imaging needs.
- Assisted Usage
- Self Usage
For training or assisted usage, please contact email@example.com
570 Westwood Plaza, Building 114
Los Angeles, CA 90095
Director: Hong Zhou
Technical Director: Xing Zhang
Associate Director: Ivo Atanasov